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KMID : 0385020030190030127
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Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 3 p.127 ~ p.141
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Four-Week Repeated-Dose Toxicity Study on Pinellia Extract
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Lee Ji-Eun
Nam Sang-Yoon
Yun Young-Won
Lee Beom-Jun
Kim Ha-Jung
Choi Ehn-Kyoung
Kim Yun-Bae
Lee Chang-Hee
Chai Hee-Youl
Kim Dae-Joong
Ahn Byeong-Woo
Kang Hyun-Gu
Lee Ki-Chang
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Abstract
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Repeated-dose toxicity of Pinellia extract was investigated in male and female Sprague-Dawley rats. Water extract of Pinellia ternata was orally administered to rats at dose levels of 50, 100, 200, 500, 1,000 or 2,000 mg/kg/day for 28 days. As a result, no clinical signs and changes in the body weight gain of rats were observed throughout the experimental period, although the body weights intermittently fluctuated in some groups. Also, daily feed and water consumptions exhibited week-to-week changes, which did not show a dose-dependency. In blood analyses, there was a trend of increase in white blood cells including neutrophils and lymphocytes in females treated with high doses (>500 mg/kg) of Pinellia. In contrast, total protein, albumin and calcium levels were relatively high in male rats treated with Pinellia, compared with those of control. In general, thymus and ovary weights decreased in males and females, respectively, following Pinellia treatment. However, no significant lesions were observed from histopathological examinations. In spite of some alterations in body weights, feed and water consumptions, hematological and serum biochemical parameters and organ weights, such effects were not considered to include toxicopathological meaning, based on the lack of dose-dependency and gender relationship. Taken together, it is suggested that long-term treatment with the water extract of Pinellia might not exert considerable toxic effects.
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KEYWORD
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Pinellia extract, 4-week repeated-dose toxicity
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